28WE

Crystal structure of the human METTL16 Methyltransferase Domain in complex with a bisubstrate analogue (BA2)

Summary for 28WE

• Entry DOI: 10.2210/pdb28we/pdb
• Descriptor: RNA N(6)-adenosine-methyltransferase METTL16, 1,2-ETHANEDIOL, (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid, ... (6 entities in total)
• Functional Keywords: mettl16, methyltransferase, bisubstrate analogue, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 34664.68

Authors

Stamm, F.,Caflisch, A. (deposition date: 2026-02-23, release date: 2026-10-14, Last modification date: 2026-10-21)

• Primary citation: Stamm, F.,Wan, Z.,Vargas-Rosales, P.A.,Corbeski, I.,Braud, E.,Iannazzo, L.,Cui, Q.,Caflisch, A.; Catalysis Tuned for Metabolic Sensing: Dynamics and Mechanism of the RNA Methyltransferase METTL16; Rsc Chem Biol, 2026; DOI: 10.1039/D6CB00242K

Experimental method

X-RAY DIFFRACTION (2.29 Å)