28WE
Crystal structure of the human METTL16 Methyltransferase Domain in complex with a bisubstrate analogue (BA2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA N(6)-adenosine-methyltransferase METTL16 | polymer | 292 | 33402.6 | 1 | UniProt (Q86W50) Pfam (PF05971) | Homo sapiens (human) | Methyltransferase 10 domain-containing protein,Methyltransferase-like protein 16,U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase |
| 2 | B, C, D, E, F... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 3 | H (A) | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid | non-polymer | 660.6 | 1 | Chemie (HZ2) PubChem (137552762) | |||
| 4 | I, J (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) PubChem (1061) | |||
| 5 | K (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) PubChem (813) | |||
| 6 | L (A) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 1 - 291 (UniProt: Q86W50)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33402.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1262.1 | |
| All* | Total formula weight | 34664.7 |
