27UH

Crystal structure of a de novo-designed VHH targeting S100A4

Summary for 27UH

• Entry DOI: 10.2210/pdb27uh/pdb
• Descriptor: S100A4_VHH-N20, Protein S100-A4, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: s100a4, ppiflow, designed vhh, dingle digit nanomolar binder, de novo protein
• Biological source: synthetic construct; More
• Total number of polymer chains: 8
• Total formula weight: 103451.32

Authors

Wang, S.,Yu, Q.L.,Tian, B.H.,Qin, X.Y.,Chen, M.C. (deposition date: 2026-06-12, release date: 2026-08-05)

• Primary citation: Yu, Q.L.,Guo, L.Y.,Qin, X.Y.,Huang, X.K.,Tian, B.H.,Wang, H.Z.,Liu, Y.,Wang, S.,Lang, Y.Z.,Shen, Z.H.Y.,Lin, J.,Chen, M.C.; High-Affinity Protein Binder Design via Flow Matching and In Silico Maturation; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.82 Å)