25CG

Structure of hTRPC3 E603A/V637A/K607A mutant

Summary for 25CG

Entry DOI	10.2210/pdb25cg/pdb
EMDB information	80010
Descriptor	Short transient receptor potential channel 3, CALCIUM ION, ZINC ION, ... (4 entities in total)
Functional Keywords	trpc3, 4f peptide, no dag binding state, metal transport
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	384638.70
Authors	Chen, L.,Tan, Y. (deposition date: 2026-03-29, release date: 2026-11-11)
Primary citation	Zang, J.,Tan, Y.,Chen, Y.,Guo, W.,Zhao, X.,Peng, H.,Chen, L. Structural mechanism of TRPC3 channel activation by the moonwalker mutation. Cell Discov, 12:-, 2026 Cited by PubMed: 42957638 DOI: 10.1038/s41421-026-00936-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.78 Å)

Structure validation