24SP

Human KRAS WT (GDP-bound) in complex with macrocyclic peptide inhibitor AP6296

This is a non-PDB format compatible entry.

Summary for 24SP

• Entry DOI: 10.2210/pdb24sp/pdb
• Descriptor: Isoform 2B of GTPase KRas, AP6296, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: kras, macrocyclic peptide, oncology, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 44447.42

Authors

Yamano, T.,Kage, M.,Fukami, T.A.,Tanada, M.,Irie, M.,Torizawa, T. (deposition date: 2026-03-19, release date: 2026-09-16)

• Primary citation: Kage, M.,Kawada, H.,Takano, K.,Matsuo, A.,Murata, Y.,Hashimoto, S.,Tamiya, M.,Kotake, T.,Kuramoto, S.,Yamano, T.,Irie, M.,Ohara, K.,Sakurai, Y.,Nomura, K.,Morita, Y.,Hayashi, R.,Wakamiya, Y.,Takei, K.,Tanaka, H.,Nishimura, Y.,Iikura, H.,Shiraishi, T.,Tanada, M.; Exploiting Bridged Conformations for Precise Molecular Recognition in the Design of KRAS-Selective, Orally Available Macrocyclic Peptides; J.Am.Chem.Soc., 2026; DOI: 10.1021/jacs.6c14212

Experimental method

X-RAY DIFFRACTION (1.45 Å)