24SP
Human KRAS WT (GDP-bound) in complex with macrocyclic peptide inhibitor AP6296
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 2B of GTPase KRas | polymer | 179 | 20092.5 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | C, D (I, J) | AP6296 | polymer | 12 | 1484.2 | 2 | synthetic construct | ||
| 3 | E, L (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 4 | F, G, H, I, M (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | J, K, N, O (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 6 | P, Q, R, S (A, B, I, J) | water | water | 18.0 | 239 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 174 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43153.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1294.0 | |
| All* | Total formula weight | 44447.4 |
