23EW

Cryo-EM structure of human ATR-ATRIP complex with Berzosertib

This is a non-PDB format compatible entry.

Summary for 23EW

• Entry DOI: 10.2210/pdb23ew/pdb
• EMDB information: 68913
• Descriptor: Serine/threonine-protein kinase ATR, ATR-interacting protein, VE-822, ... (4 entities in total)
• Functional Keywords: atr, topbp1, chk1, dna repair, nuclear protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 776452.81

Authors

Wang, L.,Wang, M.,Zhao, L.,Rao, Q.,Wu, H.,Ma, B.,Wang, J.,Zheng, J.,Li, Y.,Xu, Y.,Guo, J.,Cheng, J.,Qiao, S. (deposition date: 2026-02-04, release date: 2026-08-26)

• Primary citation: Wang, L.,Wang, M.,Zhao, L.,Rao, Q.,Wu, H.,Ma, B.,Wang, J.,Zheng, J.,Li, Y.,Xu, Y.,Guo, J.,Cheng, J.,Qiao, S.; Mechanistic insights into phosphorylation-driven activation and therapeutic inhibition of human ATR-ATRIP; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.7 Å)