23ES

Crystal structure of human PKMYT1 protein kinase domain with Naphthyridinone Inhibitor compound 11

This is a non-PDB format compatible entry.

Summary for 23ES

• Entry DOI: 10.2210/pdb23es/pdb
• Descriptor: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 3-azanyl-5-chloranyl-4-(7-fluoranyl-2H-indazol-4-yl)-7-methyl-1H-1,6-naphthyridin-2-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, protein kinase, tyrosine- and threonine-specific kinase, membrane-associated protein kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 64601.87

Authors

Xu, Z.,Chen, S. (deposition date: 2026-02-04, release date: 2026-03-25)

• Primary citation: Xu, Z.H.,Chen, S.; Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.74 Å)