21RT

Cryo-EM structure of mouse myeloperoxidase in complex with Fab fragments of antibodies mAb-A46 and mAb-B88

Summary for 21RT

• Entry DOI: 10.2210/pdb21rt/pdb
• EMDB information: 67951
• Descriptor: mAb-A46 Fab Heavy chain, mAb-A46 Fab Light chain, mAb-B88 Fab Heavy chain, ... (9 entities in total)
• Functional Keywords: myeloperoxidase, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 6
• Total formula weight: 164247.72

Authors

Fujii, T.,Irie, M.,Torizawa, T. (deposition date: 2025-12-23, release date: 2026-09-16)

• Primary citation: Nishide, M.,Matsushita, H.,Mizuno, Y.,Nishimura, K.,Lelliott, P.,Kawada, S.,Fujii, T.,Kamikawaji, S.,Nonaka, T.,Motooka, D.,Metsugi, S.,Shimagami, H.,Miyamoto, A.,Kato, Y.,Tsujimoto, K.,Edahiro, R.,Shirai, Y.,Yamamoto, Y.,Naito, Y.,Konaka, H.,Izumi, M.,Naito, M.,Nakanishi, Y.,Namba, T.,Inoue, K.,Takahashi, A.,Mizui, M.,Nakazawa, S.,Kakuta, Y.,Funakoshi, K.,Terada, M.,Irie, M.,Torizawa, T.,Omiya, R.,Smith, N.,Isaka, Y.,Nonomura, N.,Okada, Y.,Hattori, K.,Narazaki, M.,Kumanogoh, A.; Epitope-diverse autoantibodies induce neutrophil-epithelial niches driving kidney injury in ANCA-associated glomerulonephritis; J.Exp.Med., 2026; DOI: 10.1084/jem.20260506

Experimental method

ELECTRON MICROSCOPY (2.95 Å)