21RT

Cryo-EM structure of mouse myeloperoxidase in complex with Fab fragments of antibodies mAb-A46 and mAb-B88

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	mAb-A46 Fab Heavy chain	polymer	224	24220.0	1		Mus musculus
2	B (B)	mAb-A46 Fab Light chain	polymer	213	23521.1	1		Mus musculus
3	C (C)	mAb-B88 Fab Heavy chain	polymer	224	23995.0	1		Mus musculus
4	D (D)	mAb-B88 Fab Light chain	polymer	214	23874.4	1		Mus musculus
5	E (E)	Myeloperoxidase light chain	polymer	114	13020.7	1	UniProt (P11247)	Mus musculus (house mouse)
6	F (F)	Myeloperoxidase	polymer	476	54517.6	1	UniProt (Q6RFG4)	Mus musculus (house mouse)
7	G (E)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)
8	H, I (F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG) PubChem (24139)
9	J (F)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA) PubChem (271)

Sequence modifications

F: 253 - 718 (UniProt: Q6RFG4)

PDB	External Database	Details
His 719	-	expression tag
His 720	-	expression tag
His 721	-	expression tag
His 722	-	expression tag
His 723	-	expression tag
His 724	-	expression tag
His 725	-	expression tag
His 726	-	expression tag
His 727	-	expression tag
His 728	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	163148.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1099.0
All*	Total formula weight	164247.7

*Water molecules are not included.