21OA

Crystal structure of human MEK2 in complex with Refametinib

Summary for 21OA

• Entry DOI: 10.2210/pdb21oa/pdb
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 2, MAGNESIUM ION, N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide, ... (5 entities in total)
• Functional Keywords: refametinib, ser/thr kinase, transferase, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 239330.64

Authors

Cheon, S.W.,Han, B.W. (deposition date: 2025-12-21, release date: 2026-10-28)

• Primary citation: Cheon, S.W.,Han, B.W.; Crystal structure of human MEK2 in complex with Refametinib; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.3 Å)