21OA
Crystal structure of human MEK2 in complex with Refametinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Dual specificity mitogen-activated protein kinase kinase 2 | polymer | 346 | 38785.6 | 6 | UniProt (P36507) | Homo sapiens (human) | MAP kinase kinase 2,MAPKK 2,ERK activator kinase 2,MAPK/ERK kinase 2,MEK 2 |
| 2 | G, J, M, R, U... (A, B, C, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) PubChem (888) | |||
| 3 | H, L, O, Q, T... (A, B, C, D, E...) | N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide | non-polymer | 572.3 | 6 | Chemie (VRA) PubChem (44182295) | |||
| 4 | I, K, N, P, S... (A, B, C, D, E...) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 6 | Chemie (ANP) | |||
| 5 | AA, BA, CA, DA, Y... (C, D, E, F, A...) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 232713.6 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 6617.0 | |
| All* | Total formula weight | 239330.6 |
