21DU

Cryo-EM structure of the apomorphine bound ADGRG6-Gs complex

Summary for 21DU

• Entry DOI: 10.2210/pdb21du/pdb
• EMDB information: 67602
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, adgrg6, membrane protein/immune system, membrane protein-immune system complex
• Biological source: Homo sapiens; More
• Total number of polymer chains: 5
• Total formula weight: 160791.76

Authors

Han, S.,Wu, B.,Zhao, Q. (deposition date: 2025-12-09, release date: 2026-02-11)

• Primary citation: Qiu, N.,Xu, W.,Xu, T.,Xie, W.,Jiang, Y.,Zhong, Z.,Ma, L.,Zhao, Q.,Wu, B.,Han, S.; Extra-helical allosteric binding site of apomorphine in ADGRG6; Cell Discov, 12:9-, 2026; DOI: 10.1038/s41421-025-00866-1

Experimental method

ELECTRON MICROSCOPY (2.9 Å)