21DU
Cryo-EM structure of the apomorphine bound ADGRG6-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha | polymer | 246 | 28430.3 | 1 | Homo sapiens | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P62873) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | nb35 | polymer | 162 | 17540.7 | 1 | Lama glama | ||
| 5 | E (R) | Adhesion G-protein coupled receptor G6 | polymer | 605 | 67947.9 | 1 | UniProt (Q86SQ4) | Homo sapiens (human) | Developmentally regulated G-protein-coupled receptor,G-protein coupled receptor 126,Vascular inducible G protein-coupled receptor |
| 6 | F (R) | (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol | non-polymer | 267.3 | 1 | Chemie (OR9) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: 578 - 1136 (UniProt: Q86SQ4)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | initiating methionine |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 1137 | - | expression tag |
| Phe 1138 | - | expression tag |
| Leu 1139 | - | expression tag |
| Glu 1140 | - | expression tag |
| Val 1141 | - | expression tag |
| Leu 1142 | - | expression tag |
| Phe 1143 | - | expression tag |
| Gln 1144 | - | expression tag |
| Gly 1145 | - | expression tag |
| Pro 1146 | - | expression tag |
| Trp 1147 | - | expression tag |
| Ser 1148 | - | expression tag |
| His 1149 | - | expression tag |
| Pro 1150 | - | expression tag |
| Gln 1151 | - | expression tag |
| Phe 1152 | - | expression tag |
| Glu 1153 | - | expression tag |
| Lys 1154 | - | expression tag |
| Gly 1155 | - | expression tag |
| Gly 1156 | - | expression tag |
| Gly 1157 | - | expression tag |
| Ser 1158 | - | expression tag |
| Gly 1159 | - | expression tag |
| Gly 1160 | - | expression tag |
| Gly 1161 | - | expression tag |
| Ser 1162 | - | expression tag |
| Gly 1163 | - | expression tag |
| Gly 1164 | - | expression tag |
| Ser 1165 | - | expression tag |
| Ala 1166 | - | expression tag |
| Trp 1167 | - | expression tag |
| Ser 1168 | - | expression tag |
| His 1169 | - | expression tag |
| Pro 1170 | - | expression tag |
| Gln 1171 | - | expression tag |
| Phe 1172 | - | expression tag |
| Glu 1173 | - | expression tag |
| Lys 1174 | - | expression tag |
| Asp 1175 | - | expression tag |
| Tyr 1176 | - | expression tag |
| Lys 1177 | - | expression tag |
| Asp 1178 | - | expression tag |
| Asp 1179 | - | expression tag |
| Asp 1180 | - | expression tag |
| Asp 1181 | - | expression tag |
| Lys 1182 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 160524.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 267.3 | |
| All* | Total formula weight | 160791.8 |
