20YC

Cryo-EM structure of GPR174-Gi complex

Summary for 20YC

• Entry DOI: 10.2210/pdb20yc/pdb
• EMDB information: 67392
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Probable G-protein coupled receptor 174, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (4 entities in total)
• Functional Keywords: complex, selectivity, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 124057.38

Authors

Dong, Y.-J.,Xi, K.,Zhang, Y.-Z.,Xue, J.-H.,Shen, D.-D.,Zang, S.-K.,Zhao, R.-Z.,Qi, H.,Mao, C.-Y.,Wang, W.-W.,Zhang, Y. (deposition date: 2025-12-02, release date: 2026-04-15)

• Primary citation: Dong, Y.-J.,Xi, K.,Zhang, Y.-Z.,Xue, J.-H.,Shen, D.-D.,Zang, S.-K.,Zhao, R.-Z.,Qi, H.,Mao, C.-Y.,Wang, W.-W.,Zhang, Y.; Hydration network drives activation and G protein selectivity in GPR174; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.4 Å)