1ZYR

Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin

Summary for 1ZYR

• Entry DOI: 10.2210/pdb1zyr/pdb
• Related: 1I6H 1IW7 1K83 1SMY 1YNJ 1YNN
• Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase subunit beta' chain, ... (8 entities in total)
• Functional Keywords: rna polymerase; streptolydigin; transcription; holoenzyme, transcription, transferase
• Biological source: Thermus thermophilus; More
• Total number of polymer chains: 12
• Total formula weight: 854782.62

Authors

Tuske, S.,Sarafianos, S.G.,Wang, X.,Hudson, B.,Sineva, E.,Mukhopadhyay, J.,Birktoft, J.J.,Leroy, O.,Ismail, S.,Clark, A.D.,Dharia, C.,Napoli, A.,Laptenko, O.,Lee, J.,Borukhov, S.,Ebright, R.H.,Arnold, E. (deposition date: 2005-06-10, release date: 2005-09-13, Last modification date: 2023-08-23)

• Primary citation: Tuske, S.,Sarafianos, S.G.,Wang, X.,Hudson, B.,Sineva, E.,Mukhopadhyay, J.,Birktoft, J.J.,Leroy, O.,Ismail, S.,Clark, A.D.,Dharia, C.,Napoli, A.,Laptenko, O.,Lee, J.,Borukhov, S.,Ebright, R.H.,Arnold, E.; Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.; Cell(Cambridge,Mass.), 122:541-552, 2005; PubMed: 16122422; DOI: 10.1016/j.cell.2005.07.017

Experimental method

X-RAY DIFFRACTION (3 Å)