1ZXL

Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives

1ZXL の概要

• エントリーDOI: 10.2210/pdb1zxl/pdb
• 関連するPDBエントリー: 1NHD 1NHG 1NHW 1NNU 1ZSN 1ZW1 1ZXB
• 分子名称: enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE (3 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78285.22

構造登録者

Freundlich, J.S.,Anderson, J.W.,Sarantakis, D.,Shieh, H.M.,Yu, M.,Lucumi, E.,Kuo, M.,Schiehser, G.A.,Jacobus, D.P.,Jacobs Jr., W.R.,Fidock, D.A.,Sacchettini, J.C. (登録日: 2005-06-08, 公開日: 2006-06-13, 最終更新日: 2023-08-23)

• 主引用文献: Freundlich, J.S.,Anderson, J.W.,Sarantakis, D.,Shieh, H.M.,Yu, M.,Valderramos, J.C.,Lucumi, E.,Kuo, M.,Jacobs, W.R.,Fidock, D.A.,Schiehser, G.A.,Jacobus, D.P.,Sacchettini, J.C.; Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives.; Bioorg.Med.Chem.Lett., 15:5247-5252, 2005; PubMed: 16198563; DOI: 10.1016/j.bmcl.2005.08.044

実験手法

X-RAY DIFFRACTION (3 Å)