1ZTZ
Crystal structure of HIV protease- metallacarborane complex
Summary for 1ZTZ
Entry DOI | 10.2210/pdb1ztz/pdb |
Related | 1NH0 |
Descriptor | PROTEASE RETROPEPSIN, autoproteolytic tetrapeptide, COBALT BIS(1,2-DICARBOLLIDE), ... (4 entities in total) |
Functional Keywords | rational drug design; hiv protease inhibitors; aspartic proteases; carboranes; metallacarboranes, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 3 |
Total formula weight | 22545.41 |
Authors | Cigler, P.,Kozisek, M.,Rezacova, P.,Brynda, J.,Otwinowski, Z.,Sedlacek, J.,Bodem, J.,Kraeusslich, H.-G.,Kral, V.,Konvalinka, J. (deposition date: 2005-05-28, release date: 2005-11-01, Last modification date: 2023-08-23) |
Primary citation | Cigler, P.,Kozisek, M.,Rezacova, P.,Brynda, J.,Otwinowski, Z.,Pokorna, J.,Plesek, J.,Gruner, B.,Doleckova-Maresova, L.,Masa, M.,Sedlacek, J.,Bodem, J.,Kraeusslich, H.-G.,Kral, V.,Konvalinka, J. From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease Proc.Natl.Acad.Sci.USA, 102:15394-15399, 2005 Cited by PubMed: 16227435DOI: 10.1073/pnas.0507577102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
Download full validation report