1ZTZ
Crystal structure of HIV protease- metallacarborane complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEASE RETROPEPSIN | polymer | 99 | 10804.8 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | C (P) | autoproteolytic tetrapeptide | polymer | 4 | 288.3 | 1 | |||
| 3 | D, E (B, P) | COBALT BIS(1,2-DICARBOLLIDE) | non-polymer | 323.7 | 2 | Chemie (CB5) | |||
| 4 | F, G, H (A, B, P) | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 75 | engineered mutation |
| Ile 33 | Leu 101 | engineered mutation |
| Ile 63 | Leu 131 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 21897.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 647.5 | |
| All* | Total formula weight | 22545.4 |
