1ZRB

Thrombin in complex with an azafluorenyl inhibitor 23b

Summary for 1ZRB

• Entry DOI: 10.2210/pdb1zrb/pdb
• Descriptor: thrombin, 11-peptide hirudin fragment, 3-AZA-9-HYDROXY-9-FLUORENYLCARBONYL-L-PROLYL-2-AMINOMETHYL-5-CHLOROBENZYLAMIDE, N-OXIDE, ... (4 entities in total)
• Functional Keywords: thrombin; thrombin inhibitor complex, blood clotting, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734; Secreted: P28504
• Total number of polymer chains: 2
• Total formula weight: 35064.45

Authors

Stauffer, K.J.,Williams, P.D.,Selnick, H.G.,Nantermet, P.G.,Newton, C.L.,Homnick, C.F.,Zrada, M.M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Pietrak, B.L.,Lyle, E.A.,Singh, R.,Miller-Stein, C.,White, R.B.,Wong, B.,Wallace, A.A.,Sitko, G.R.,Cook, J.J.,Holahan, M.A.,Stranieri-Michener, M.,Leonard, Y.M.,Lynch Jr., J.J.,McMasters, D.R.,Yan, Y. (deposition date: 2005-05-19, release date: 2005-06-07, Last modification date: 2013-03-13)

• Primary citation: Stauffer, K.J.,Williams, P.D.,Selnick, H.G.,Nantermet, P.G.,Newton, C.L.,Homnick, C.F.,Zrada, M.M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Pietrak, B.L.,Lyle, E.A.,Singh, R.,Miller-Stein, C.,White, R.B.,Wong, B.,Wallace, A.A.,Sitko, G.R.,Cook, J.J.,Holahan, M.A.,Stranieri-Michener, M.,Leonard, Y.M.,Lynch Jr., J.J.,McMasters, D.R.,Yan, Y.; 9-hydroxyazafluorenes and their use in thrombin inhibitors; J.Med.Chem., 48:2282-2293, 2005; PubMed: 15801822; DOI: 10.1021/jm049423s

Experimental method

X-RAY DIFFRACTION (1.9 Å)