1ZQ5

Crystal structure of human androgenic 17beta-hydroxysteroid dehydrogenase type 5 in complexed with a potent inhibitor EM1404

Summary for 1ZQ5

• Entry DOI: 10.2210/pdb1zq5/pdb
• Related: 1XF0
• Descriptor: Aldo-keto reductase family 1 member C3, ACETATE ION, 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN, ... (5 entities in total)
• Functional Keywords: (alpha/beta)8 barrel, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P42330
• Total number of polymer chains: 1
• Total formula weight: 38094.20

Authors

Qiu, W.,Zhou, M.,Ghanmi, D.,Luu-The, V.,Labrie, F.,Lin, S.X. (deposition date: 2005-05-18, release date: 2006-12-12, Last modification date: 2023-08-23)

• Primary citation: Qiu, W.,Zhou, M.,Mazumdar, M.,Azzi, A.,Ghanmi, D.,Luu-The, V.,Labrie, F.,Lin, S.X.; Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase.; J.Biol.Chem., 282:8368-8379, 2007; PubMed: 17166832; DOI: 10.1074/jbc.M606784200

Experimental method

X-RAY DIFFRACTION (1.3 Å)