1XF0

Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) complexed with delta4-androstene-3,17-dione and NADP

Summary for 1XF0

Entry DOI	10.2210/pdb1xf0/pdb
Related	1RY0 1RY8 1S1P 1S1R 1S2A 1S2C
Descriptor	Aldo-keto reductase family 1 member C3, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	alpha/beta barrel, beta-hairpin, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P42330
Total number of polymer chains	1
Total formula weight	37985.07
Authors	Qiu, W.,Zhou, M.,Labrie, F.,Lin, S.-X. (deposition date: 2004-09-13, release date: 2004-10-26, Last modification date: 2023-08-23)
Primary citation	Qiu, W.,Zhou, M.,Labrie, F.,Lin, S.-X. Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues Mol.Endocrinol., 18:1798-1807, 2004 Cited by PubMed: 15087468 DOI: 10.1210/me.2004-0032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation