1ZQ5

Crystal structure of human androgenic 17beta-hydroxysteroid dehydrogenase type 5 in complexed with a potent inhibitor EM1404

1ZQ5 の概要

• エントリーDOI: 10.2210/pdb1zq5/pdb
• 関連するPDBエントリー: 1XF0
• 分子名称: Aldo-keto reductase family 1 member C3, ACETATE ION, 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN, ... (5 entities in total)
• 機能のキーワード: (alpha/beta)8 barrel, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P42330
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38094.20

構造登録者

Qiu, W.,Zhou, M.,Ghanmi, D.,Luu-The, V.,Labrie, F.,Lin, S.X. (登録日: 2005-05-18, 公開日: 2006-12-12, 最終更新日: 2023-08-23)

• 主引用文献: Qiu, W.,Zhou, M.,Mazumdar, M.,Azzi, A.,Ghanmi, D.,Luu-The, V.,Labrie, F.,Lin, S.X.; Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase.; J.Biol.Chem., 282:8368-8379, 2007; PubMed: 17166832; DOI: 10.1074/jbc.M606784200

実験手法

X-RAY DIFFRACTION (1.3 Å)