1ZNB

METALLO-BETA-LACTAMASE

Summary for 1ZNB

• Entry DOI: 10.2210/pdb1znb/pdb
• Descriptor: METALLO-BETA-LACTAMASE, ZINC ION, SODIUM ION, ... (4 entities in total)
• Functional Keywords: hydrolase (beta-lactamase), metallo beta-lactamase zinc
• Biological source: Bacteroides fragilis
• Total number of polymer chains: 2
• Total formula weight: 50848.60

Authors

Concha, N.O.,Herzberg, O. (deposition date: 1996-06-06, release date: 1997-01-11, Last modification date: 2024-02-14)

Primary citation

Concha, N.O.,Rasmussen, B.A.,Bush, K.,Herzberg, O.
Crystal structure of the wide-spectrum binuclear zinc beta-lactamase from Bacteroides fragilis.
Structure, 4:823-836, 1996

PubMed Abstract: The metallo-beta-lactamase from Bacteroides fragilis hydrolyzes a wide range of beta-lactam antibiotics, and is not clinically susceptible to any known beta-lactamase inhibitors. B. fragilis is associated with post-surgery hospital infections, and there has been a recent report of plasmid-mediated dissemination of the enzyme. Effective inhibitors are therefore urgently needed. Knowledge of the three-dimensional structure will aid in the drug design effort.

PubMed: 8805566
DOI: 10.1016/S0969-2126(96)00089-5

Experimental method

X-RAY DIFFRACTION (1.85 Å)