1ZNB

METALLO-BETA-LACTAMASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
B	0008270	molecular_function	zinc ion binding
B	0008800	molecular_function	beta-lactamase activity
B	0017001	biological_process	antibiotic catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	ZN2
A	HIS99
A	HIS101
A	HIS162
A	HOH250

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	HOH250
A	HOH251
A	ZN1
A	ASP103
A	CYS181
A	HIS223

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 3

Chain	Residue
A	ASN55
A	ASP69
A	ASP103
A	HOH255
A	HOH263

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	ZN2
B	HIS99
B	HIS101
B	HIS162
B	HOH250

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	ZN1
B	ASP103
B	CYS181
B	HIS223
B	HOH250
B	HOH251

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 3

Chain	Residue
B	ASN55
B	ASP69
B	ASP103
B	HOH255
B	HOH264

---

Functional Information from PROSITE/UniProt

site_id	PS00743
Number of Residues	20
Details	BETA_LACTAMASE_B_1 Beta-lactamases class B signature 1. IpNHwHGDciGGlgylqkk.G

Chain	Residue	Details
A	ILE96-GLY115

---

site_id	PS00744
Number of Residues	13
Details	BETA_LACTAMASE_B_2 Beta-lactamases class B signature 2. PtenILfGgCMLK

Chain	Residue	Details
A	PRO172-LYS184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10210203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12019104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8805566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9416622","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9545432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9578564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9761816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12019104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8805566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9416622","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9545432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9578564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9761816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9545432","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12019104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9545432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9578564","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP103
A	ASN193

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
B	ASP103
B	ASN193

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP103

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
B	ASP103

---

site_id	MCSA1
Number of Residues	8
Details	M-CSA 15

Chain	Residue	Details
A	HIS99	metal ligand
A	HIS101	metal ligand
A	ASP103	metal ligand
A	HIS162	metal ligand
A	CYS181	metal ligand
A	LYS184	electrostatic stabiliser, steric role
A	ASN193	electrostatic stabiliser, hydrogen bond donor
A	HIS223	metal ligand

---

site_id	MCSA2
Number of Residues	8
Details	M-CSA 15

Chain	Residue	Details
B	HIS99	metal ligand
B	HIS101	metal ligand
B	ASP103	metal ligand
B	HIS162	metal ligand
B	CYS181	metal ligand
B	LYS184	electrostatic stabiliser, steric role
B	ASN193	electrostatic stabiliser, hydrogen bond donor
B	HIS223	metal ligand

---