1ZKL

Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases

Summary for 1ZKL

Entry DOI	10.2210/pdb1zkl/pdb
Descriptor	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	pde, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Isoform PDE7A1: Cytoplasm, cytosol. Isoform PDE7A2: Cytoplasm: Q13946
Total number of polymer chains	1
Total formula weight	41075.08
Authors	Wang, H.,Liu, Y.,Chen, Y.,Robinson, H.,Ke, H. (deposition date: 2005-05-03, release date: 2005-07-05, Last modification date: 2024-02-14)
Primary citation	Wang, H.,Liu, Y.,Chen, Y.,Robinson, H.,Ke, H. Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7 J.Biol.Chem., 280:30949-30955, 2005 Cited by PubMed: 15994308 DOI: 10.1074/jbc.M504398200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation