1ZJ7
Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
Summary for 1ZJ7
Entry DOI | 10.2210/pdb1zj7/pdb |
Related | 1FQX 1IIQ 1LZQ 1M0B 1Z8C 1ZBG 1ZLF |
Related PRD ID | PRD_000386 |
Descriptor | PROTEASE RETROPEPSIN, N-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide (3 entities in total) |
Functional Keywords | hiv, protease, peptidomimetic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 1 |
Total formula weight | 11523.58 |
Authors | Skalova, T.,Dohnalek, J.,Duskova, J.,Petrokova, H.,Hasek, J. (deposition date: 2005-04-28, release date: 2006-05-09, Last modification date: 2023-08-23) |
Primary citation | Skalova, T.,Dohnalek, J.,Duskova, J.,Petrokova, H.,Hradilek, M.,Soucek, M.,Konvalinka, J.,Hasek, J. HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site J.Med.Chem., 49:5777-5784, 2006 Cited by PubMed: 16970402DOI: 10.1021/jm0605583 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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