1ZJ7
Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | PROTEASE RETROPEPSIN | polymer | 99 | 10819.8 | 1 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | A | N-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide | non-polymer | 703.8 | 1 | BIRD (PRD_000386) Chemie (0ZT) | |||
| 3 | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Val 71 | Ala 139 | engineered mutation |
| Thr 82 | Val 150 | engineered mutation |
| Val 84 | Ile 152 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10819.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 703.8 | |
| All* | Total formula weight | 11523.6 |
