1ZJ7

Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2

1ZJ7 の概要

• エントリーDOI: 10.2210/pdb1zj7/pdb
• 関連するPDBエントリー: 1FQX 1IIQ 1LZQ 1M0B 1Z8C 1ZBG 1ZLF
• 関連するBIRD辞書のPRD_ID: PRD_000386
• 分子名称: PROTEASE RETROPEPSIN, N-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide (3 entities in total)
• 機能のキーワード: hiv, protease, peptidomimetic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11523.58

構造登録者

Skalova, T.,Dohnalek, J.,Duskova, J.,Petrokova, H.,Hasek, J. (登録日: 2005-04-28, 公開日: 2006-05-09, 最終更新日: 2023-08-23)

• 主引用文献: Skalova, T.,Dohnalek, J.,Duskova, J.,Petrokova, H.,Hradilek, M.,Soucek, M.,Konvalinka, J.,Hasek, J.; HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site; J.Med.Chem., 49:5777-5784, 2006; PubMed: 16970402; DOI: 10.1021/jm0605583

実験手法

X-RAY DIFFRACTION (1.93 Å)