1Z8C
Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
Summary for 1Z8C
Entry DOI | 10.2210/pdb1z8c/pdb |
Related | 1FQX 1IIQ 1LZQ 1M0B 1ZBG 1ZJ7 1ZLF |
Related PRD ID | PRD_000385 |
Descriptor | PROTEASE RETROPEPSIN, N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | hiv, protease, peptidomimetic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22559.55 |
Authors | Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J. (deposition date: 2005-03-30, release date: 2006-03-21, Last modification date: 2024-10-09) |
Primary citation | Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J. Mutational Study of Pseudopeptide Inhibitor Binding to HIV-1 Protease; Analysis of Four X-ray Structures To be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report