1Z89

Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor

Summary for 1Z89

Entry DOI	10.2210/pdb1z89/pdb
Related	1US0 1Z8A
Descriptor	aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE, ... (4 entities in total)
Functional Keywords	sulfonyl-pyridazinone, tim-barrel, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36966.48
Authors	Steuber, H.,Zentgraf, M.,Podjarny, A.,Heine, A.,Klebe, G. (deposition date: 2005-03-30, release date: 2006-03-14, Last modification date: 2023-08-23)
Primary citation	Steuber, H.,Zentgraf, M.,Podjarny, A.,Heine, A.,Klebe, G. High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group. J.Mol.Biol., 356:45-56, 2006 Cited by PubMed: 16337231 DOI: 10.1016/j.jmb.2005.10.067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation