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1Z62

Indirubin-3'-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sites

Summary for 1Z62
Entry DOI10.2210/pdb1z62/pdb
Related2AMV
DescriptorGlycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID, ... (4 entities in total)
Functional Keywordsglycogenolysis, type 2 diabetes, transferase
Biological sourceOryctolagus cuniculus (rabbit)
Total number of polymer chains1
Total formula weight98544.29
Authors
Kosmopoulou, M.N.,Leonidas, D.D.,Chrysina, E.D.,Eisenbrand, G.,Oikonomakos, N.G. (deposition date: 2005-03-21, release date: 2006-03-07, Last modification date: 2011-07-13)
Primary citationKosmopoulou, M.N.,Leonidas, D.D.,Chrysina, E.D.,Eisenbrand, G.,Oikonomakos, N.G.
Indirubin-3'-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites
LETT.DRUG DES.DISCOVERY, 2:377-390, 2005
Cited by
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

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