1YW2

Mutated Mus Musculus P38 Kinase (mP38)

Summary for 1YW2

Entry DOI	10.2210/pdb1yw2/pdb
Descriptor	Mitogen-activated protein kinase 14, 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE (3 entities in total)
Functional Keywords	transferase
Biological source	Mus musculus (house mouse)
Cellular location	Cytoplasm : P47811
Total number of polymer chains	1
Total formula weight	41715.53
Authors	Laughlin, S.K.,Clark, M.P.,Djung, J.F.,Golebiowski, A.,Brugel, T.A.,Sabat, M.,Bookland, R.G.,Laufersweiler, M.J.,Vanrens, J.C.,Townes, J.A.,De, B.,Hsieh, L.C.,Xu, S.C.,Walter, R.L.,Mekel, M.J.,Janusz, M.J. (deposition date: 2005-02-16, release date: 2005-05-10, Last modification date: 2023-08-23)
Primary citation	Laughlin, S.K.,Clark, M.P.,Djung, J.F.,Golebiowski, A.,Brugel, T.A.,Sabat, M.,Bookland, R.G.,Laufersweiler, M.J.,Vanrens, J.C.,Townes, J.A.,De, B.,Hsieh, L.C.,Xu, S.C.,Walter, R.L.,Mekel, M.J.,Janusz, M.J. The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Bioorg.Med.Chem.Lett., 15:2399-2403, 2005 Cited by PubMed Abstract: 4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production. PubMed: 15837333 DOI: 10.1016/j.bmcl.2005.02.066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation