1YV5
Human farnesyl diphosphate synthase complexed with Mg and risedronate
Summary for 1YV5
Entry DOI | 10.2210/pdb1yv5/pdb |
Related | 1YQ7 |
Descriptor | Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | isoprenoid pathway, cholesterol synthesis, bisphosphonate, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43559.75 |
Authors | Kavanagh, K.L.,Guo, K.,Von Delft, F.,Arrowsmith, C.,Sundstrom, M.,Edwards, A.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2005-02-15, release date: 2005-03-01, Last modification date: 2023-10-25) |
Primary citation | Kavanagh, K.L.,Guo, K.,Dunford, J.E.,Wu, X.,Knapp, S.,Ebetino, F.H.,Rogers, M.J.,Russell, R.G.,Oppermann, U. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc.Natl.Acad.Sci.USA, 103:7829-7834, 2006 Cited by PubMed: 16684881DOI: 10.1073/pnas.0601643103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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