1YNK

Identification of Key residues of the NC6.8 Fab antibody fragment binding to synthetic sweeteners: Crystal structure of NC6.8 co-crystalized with high potency sweetener compound SC45647

1YNK の概要

• エントリーDOI: 10.2210/pdb1ynk/pdb
• 関連するPDBエントリー: 1YNL
• 分子名称: immunoglobulin kappa light chain, Ig gamma heavy chain, 2-[((R)-{[4-(AMINOMETHYL)PHENYL]AMINO}{[(1R)-1-PHENYLETHYL]AMINO}METHYL)AMINO]ETHANE-1,1-DIOL, ... (4 entities in total)
• 機能のキーワード: sweetener compound, sc45657 and nc174, immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47809.25

構造登録者

Gokulan, K.,Khare, S.,Ronning, D.R.,Linthicum, S.D.,Sacchettini, J.C.,Rupp, B. (登録日: 2005-01-24, 公開日: 2005-08-16, 最終更新日: 2023-08-23)

• 主引用文献: Gokulan, K.,Khare, S.,Ronning, D.R.,Linthicum, S.D.,Sacchettini, J.C.,Rupp, B.; Cocrystal Structures of NC6.8 Fab Identify Key Interactions for High Potency Sweetener Recognition: Implications for the Design of Synthetic Sweeteners; Biochemistry, 44:9889-9898, 2005; PubMed: 16026161; DOI: 10.1021/bi050613u

実験手法

X-RAY DIFFRACTION (2.1 Å)