1YK7

Cathepsin K complexed with a cyanopyrrolidine inhibitor

Summary for 1YK7

Entry DOI	10.2210/pdb1yk7/pdb
Descriptor	Cathepsin K, N2-[(BENZYLOXY)CARBONYL]-N1-[(3S)-1-CYANOPYRROLIDIN-3-YL]-L-LEUCINAMIDE (3 entities in total)
Functional Keywords	cathepsin, catk, cysteine, protease, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P43235
Total number of polymer chains	1
Total formula weight	23881.92
Authors	Barrett, D.G.,Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Tavares, F.X.,Willard, D.H.,Wright, L.L. (deposition date: 2005-01-17, release date: 2005-03-22, Last modification date: 2023-08-23)
Primary citation	Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Tavares, F.X.,Willard, D.H.,Wright, L.L. Novel and potent cyclic cyanamide-based cathepsin K inhibitors. Bioorg.Med.Chem.Lett., 15:1815-1819, 2005 Cited by PubMed: 15780613 DOI: 10.1016/j.bmcl.2005.02.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation