1YE4

Crystal structure of the Lys-274 to Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD+

Summary for 1YE4

Entry DOI	10.2210/pdb1ye4/pdb
Related	1YE6
Descriptor	NAD(P)H-dependent D-xylose reductase, SULFATE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	beta-alpha-barrel akr aldo-keto reductase coenzyme specificity nad, oxidoreductase
Biological source	Candida tenuis
Total number of polymer chains	4
Total formula weight	147590.94
Authors	Leitgeb, S.,Petschacher, B.,Wilson, D.K.,Nidetzky, B. (deposition date: 2004-12-28, release date: 2005-02-01, Last modification date: 2023-08-23)
Primary citation	Leitgeb, S.,Petschacher, B.,Wilson, D.K.,Nidetzky, B. Fine tuning of coenzyme specificity in family 2 aldo-keto reductases revealed by crystal structures of the Lys-274-->Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD(+) and NADP(+). FEBS Lett., 579:763-767, 2005 Cited by PubMed: 15670843 DOI: 10.1016/j.febslet.2004.12.063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation