Crystal STructure of ZipA in complex with an inhibitor

Summary for 1Y2G

DescriptorCell division protein zipA, N-METHYL-N-[3-(6-PHENYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-3-YL)PHENYL]ACETAMIDE (3 entities in total)
Functional Keywordscell cycle
Biological sourceEscherichia coli
Cellular locationCell inner membrane; Single-pass type I membrane protein P77173
Total number of polymer chains2
Total molecular weight31669.08
Mosyak, L.,Rush, T.S. (deposition date: 2004-11-22, release date: 2005-03-01, Last modification date: 2011-07-13)
Primary citation
Rush, T.S.,Grant, J.A.,Mosyak, L.,Nicholls, A.
A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction
J.Med.Chem., 48:1489-1495, 2005
PubMed: 15743191 (PDB entries with the same primary citation)
DOI: 10.1021/jm040163o
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers130.7%6.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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