1Y0H

Structure of Rv0793 from Mycobacterium tuberculosis

Summary for 1Y0H

• Entry DOI: 10.2210/pdb1y0h/pdb
• Descriptor: hypothetical protein Rv0793, ACETATE ION (3 entities in total)
• Functional Keywords: ferredoxin-like fold, alpha+beta sandwich with antiparallel beta-sheet, structural genomics, psi, protein structure initiative, tb structural genomics consortium, tbsgc, unknown function
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 22702.67

Authors

Lemieux, M.J.,Ference, C.,Cherney, M.M.,Wang, M.,Garen, C.,James, M.N.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2004-11-15, release date: 2004-12-28, Last modification date: 2024-02-14)

Primary citation

Lemieux, M.J.,Ference, C.,Cherney, M.M.,Wang, M.,Garen, C.,James, M.N.
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis
J.STRUCT.FUNCT.GENOM., 6:245-257, 2005

PubMed Abstract: Mycobacterium tuberculosis infects millions worldwide. The Structural Genomics Consortium for M. tuberculosis has targeted all genes from this bacterium in hopes of discovering and developing new therapeutic agents. Open reading frame Rv0793 from M. tuberculosis was annotated with an unknown function. The 3-dimensional structure of Rv0793 has been solved to 1.6 A resolution. Its structure is very similar to that of Streptomyces coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of polyketide antibiotics in the absence of a cofactor. It is also similar to the recently solved structure of YgiN, a quinol monooxygenase from Escherichia coli. In addition, the structure of Rv0793 is similar to several structures of other proteins with unknown function. These latter structures have been determined recently as a result of structural genomic projects for various bacterial species. In M. tuberculosis, Rv0793 and its homologs may represent a class of monooygenases acting as reactive oxygen species scavengers that are essential for evading host defenses. Since the most prevalent mode of attack by the host defense on M. tuberculosis is by reactive oxygen species and reactive nitrogen species, Rv0793 may provide a novel target to combat infection by M. tuberculosis.

PubMed: 16496224
DOI: 10.1007/s10969-005-9004-6

Experimental method

X-RAY DIFFRACTION (1.6 Å)