1XOQ

Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast

Summary for 1XOQ

• Entry DOI: 10.2210/pdb1xoq/pdb
• Related: 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOM 1XON 1XOR 1XOS 1XOT 1XOZ 1XP0
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: phosphodiesterase, pde, pde4d, roflumilast, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q08499
• Total number of polymer chains: 2
• Total formula weight: 82668.18

Authors

Card, G.L.,England, B.P.,Suzuki, Y.,Fong, D.,Powell, B.,Lee, B.,Luu, C.,Tabrizizad, M.,Gillette, S.,Ibrahim, P.N.,Artis, D.R.,Bollag, G.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Zhang, K.Y.J. (deposition date: 2004-10-06, release date: 2004-12-14, Last modification date: 2024-02-14)

• Primary citation: Card, G.L.,England, B.P.,Suzuki, Y.,Fong, D.,Powell, B.,Lee, B.,Luu, C.,Tabrizizad, M.,Gillette, S.,Ibrahim, P.N.,Artis, D.R.,Bollag, G.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Zhang, K.Y.J.; Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.; STRUCTURE, 12:2233-2247, 2004; PubMed: 15576036; DOI: 10.1016/j.str.2004.10.004

Experimental method

X-RAY DIFFRACTION (1.83 Å)