Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | HIS164 |
| A | HIS200 |
| A | ASP201 |
| A | ASP318 |
| A | HOH1010 |
| A | HOH1011 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | HOH1008 |
| A | HOH1009 |
| A | HOH1010 |
| A | ASP201 |
| A | HOH1006 |
| A | HOH1007 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 1001 |
| Chain | Residue |
| B | HIS164 |
| B | HIS200 |
| B | ASP201 |
| B | ASP318 |
| B | HOH2007 |
| B | HOH2008 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1002 |
| Chain | Residue |
| B | ASP201 |
| B | HOH2003 |
| B | HOH2004 |
| B | HOH2005 |
| B | HOH2006 |
| B | HOH2007 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1003 |
| Chain | Residue |
| A | PRO411 |
| B | GLU366 |
| B | TYR406 |
| B | HOH2051 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1003 |
| Chain | Residue |
| A | LYS262 |
| A | ILE265 |
| A | ASP266 |
| A | HOH1038 |
| B | ASN224 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1004 |
| Chain | Residue |
| A | TRP405 |
| A | HOH1085 |
| B | HOH2100 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1004 |
| Chain | Residue |
| A | ASN115 |
| A | GLU150 |
| A | ASP151 |
| A | TYR153 |
| A | ASN162 |
| A | HOH1093 |
| A | HOH1123 |
| B | GLN407 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1005 |
| Chain | Residue |
| B | SER208 |
| B | PRO356 |
| B | HOH2015 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1005 |
| Chain | Residue |
| A | PRO179 |
| A | SER295 |
| A | GLY296 |
| A | HIS389 |
| A | PRO390 |
| A | ASP391 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 415 |
| Chain | Residue |
| A | ASN115 |
| A | ALA155 |
| A | ASN161 |
| A | ASN162 |
| A | ILE163 |
| A | HOH1123 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 416 |
| Chain | Residue |
| A | LEU175 |
| A | THR178 |
| A | TRP384 |
| A | VAL388 |
| A | ASP391 |
| A | ALA392 |
| A | HOH1148 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 417 |
| Chain | Residue |
| B | PHE238 |
| B | PHE249 |
| B | ARG257 |
| B | EDO418 |
| B | HOH2097 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 418 |
| Chain | Residue |
| B | ARG257 |
| B | GLN258 |
| B | ARG261 |
| B | EDO417 |
| B | HOH2163 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 419 |
| Chain | Residue |
| A | ALA183 |
| A | VAL184 |
| A | HOH1071 |
| B | ASN115 |
| B | ARG116 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 420 |
| Chain | Residue |
| A | PHE238 |
| A | PHE249 |
| A | ARG257 |
| A | ARG261 |
| A | HOH1172 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 422 |
| Chain | Residue |
| A | SER208 |
| A | PHE340 |
| A | PRO356 |
| A | HOH1043 |
| A | HOH1181 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 425 |
| Chain | Residue |
| A | ASN224 |
| B | LYS262 |
| B | ILE265 |
| B | ASP266 |
| B | HOH2029 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 427 |
| Chain | Residue |
| B | ASN402 |
| B | EDO428 |
| B | HOH2044 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 428 |
| Chain | Residue |
| A | GLU366 |
| B | EDO427 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 429 |
| Chain | Residue |
| A | ASP151 |
| A | HIS152 |
| B | ASP374 |
| B | TYR375 |
| B | HOH2105 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 430 |
| Chain | Residue |
| B | ASP156 |
| B | VAL157 |
| B | ALA158 |
| B | GLU339 |
| B | ARG342 |
| B | HOH2037 |
| B | HOH2058 |
| B | HOH2120 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 433 |
| Chain | Residue |
| A | HIS154 |
| A | ASP203 |
| A | PRO205 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 434 |
| Chain | Residue |
| B | ASN115 |
| B | ALA155 |
| B | ASN162 |
| B | HOH2055 |
| B | HOH2181 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 441 |
| Chain | Residue |
| B | MET273 |
| B | MET277 |
| B | HOH2063 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 444 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 445 |
| Chain | Residue |
| A | ASP156 |
| A | VAL157 |
| A | ALA158 |
| A | GLU339 |
| A | ARG342 |
| A | HOH1042 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 448 |
| Chain | Residue |
| B | SER368 |
| B | PHE372 |
| B | ILE376 |
| B | ROF501 |
| site_id | DC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ROF A 502 |
| Chain | Residue |
| A | HIS160 |
| A | THR271 |
| A | MET273 |
| A | ASP318 |
| A | LEU319 |
| A | ASN321 |
| A | PRO322 |
| A | TYR329 |
| A | TRP332 |
| A | THR333 |
| A | ILE336 |
| A | MET357 |
| A | SER368 |
| A | GLN369 |
| A | PHE372 |
| A | HOH1008 |
| A | HOH1015 |
| site_id | DC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ROF B 501 |
| Chain | Residue |
| B | HIS160 |
| B | THR271 |
| B | MET273 |
| B | ASP318 |
| B | LEU319 |
| B | ASN321 |
| B | PRO322 |
| B | TYR329 |
| B | TRP332 |
| B | THR333 |
| B | ILE336 |
| B | MET357 |
| B | GLN369 |
| B | PHE372 |
| B | EDO448 |
| B | HOH2005 |
| B | HOH2009 |
| B | HOH2101 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS200-PHE211 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 | |
| Chain | Residue | Details |
| A | HIS160 | |
| A | ASN321 | |
| A | GLN369 | |
| B | HIS160 | |
| B | ASN321 | |
| B | GLN369 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS164 | |
| B | HIS164 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS200 | |
| A | ASP318 | |
| B | HIS200 | |
| B | ASP318 | |
| Chain | Residue | Details |
| A | ASP201 | |
| A | PHE372 | |
| B | ASP201 | |
| B | PHE372 | |
