1XNR

Crystal Structure of an Inosine-Cytosine Wobble Base Pair in the Context of the Decoding Center

Summary for 1XNR

Entry DOI	10.2210/pdb1xnr/pdb
Related	1IBL 1XMO 1XMQ 1XNQ
Descriptor	16S Ribosomal RNA, 16S Ribosomal protein S8, 16S Ribosomal protein S9, ... (26 entities in total)
Functional Keywords	ribosome, translation, decoding, 30s, trna modification
Biological source	Thermus thermophilus More
Total number of polymer chains	23
Total formula weight	791799.38
Authors	Murphy, F.V.,Ramakrishnan, V. (deposition date: 2004-10-05, release date: 2004-12-14, Last modification date: 2024-11-13)
Primary citation	Murphy, F.V.,Ramakrishnan, V. Structure of a purine-purine wobble base pair in the decoding center of the ribosome. Nat.Struct.Mol.Biol., 11:1251-1252, 2004 Cited by PubMed Abstract: Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I.A base pair is of an I(anti).A(anti) conformation, as predicted by Crick. Additionally, the structures enable the observation of changes in the anticodon to allow purine-purine base pairing, the 'widest' base pair geometry allowed in the wobble position. PubMed: 15558050 DOI: 10.1038/nsmb866 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation