1XLS
Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs
Summary for 1XLS
Entry DOI | 10.2210/pdb1xls/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, Orphan nuclear receptor NR1I3, Nuclear receptor coactivator 2, ... (6 entities in total) |
Functional Keywords | lbd, nuclear receptor, car, xenobiotic, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P19793 O35627 Q9WUI9 |
Total number of polymer chains | 16 |
Total formula weight | 235875.12 |
Authors | Suino, K.,peng, L.,Reynolds, R.,Li, Y.,Cha, J.-Y.,Repa, J.J.,Kliewer, S.A.,Xu, H.E. (deposition date: 2004-09-30, release date: 2004-12-28, Last modification date: 2024-02-14) |
Primary citation | Suino, K.,Peng, L.,Reynolds, R.,Li, Y.,Cha, J.Y.,Repa, J.J.,Kliewer, S.A.,Xu, H.E. The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Mol.Cell, 16:893-905, 2004 Cited by PubMed: 15610733DOI: 10.1016/j.molcel.2004.11.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.96 Å) |
Structure validation
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