1XAL

CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE (SOAK)

Summary for 1XAL

Entry DOI	10.2210/pdb1xal/pdb
Related	1NR5 1NRX 1NUA 1NVA 1NVB 1NVD 1NVE 1NVF 1XAG 1XAH 1XAI 1XAJ
Descriptor	3-dehydroquinate synthase, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	shikimate pathway, aromatic amino acid biosynthesis, dhqs, sadhqs, closed form, form b, domain movement, cyclase, lyase
Biological source	Staphylococcus aureus
Cellular location	Cytoplasm (Probable): Q6GGU4
Total number of polymer chains	2
Total formula weight	82715.81
Authors	Nichols, C.E.,Ren, J.,Leslie, K.,Dhaliwal, B.,Lockyer, M.,Charles, I.,Hawkins, A.R.,Stammers, D.K. (deposition date: 2004-08-26, release date: 2005-03-01, Last modification date: 2024-02-14)
Primary citation	Nichols, C.E.,Ren, J.,Leslie, K.,Dhaliwal, B.,Lockyer, M.,Charles, I.,Hawkins, A.R.,Stammers, D.K. Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases. J.Mol.Biol., 343:533-546, 2004 Cited by PubMed: 15465043 DOI: 10.1016/j.jmb.2004.08.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation