1XAI
CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE
Summary for 1XAI
Entry DOI | 10.2210/pdb1xai/pdb |
Related | 1NR5 1NRX 1NUA 1NVA 1NVB 1NVD 1NVE 1NVF 1XAG 1XAH 1XAJ 1XAL |
Descriptor | 3-dehydroquinate synthase, ZINC ION, [1R-(1ALPHA,3BETA,4ALPHA,5BETA)]-5-(PHOSPHONOMETHYL)-1,3,4-TRIHYDROXYCYCLOHEXANE-1-CARBOXYLIC ACID, ... (4 entities in total) |
Functional Keywords | shikimate pathway, aromatic amino acid biosynthesis, dhqs, sadhqs, closed form, form b, domain movement, cyclase, lyase |
Biological source | Staphylococcus aureus |
Cellular location | Cytoplasm (Probable): Q6GGU4 |
Total number of polymer chains | 2 |
Total formula weight | 81388.96 |
Authors | Nichols, C.E.,Ren, J.,Leslie, K.,Dhaliwal, B.,Lockyer, M.,Charles, I.,Hawkins, A.R.,Stammers, D.K. (deposition date: 2004-08-25, release date: 2005-03-01, Last modification date: 2023-08-23) |
Primary citation | Nichols, C.E.,Ren, J.,Leslie, K.,Dhaliwal, B.,Lockyer, M.,Charles, I.,Hawkins, A.R.,Stammers, D.K. Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases. J.Mol.Biol., 343:533-546, 2004 Cited by PubMed: 15465043DOI: 10.1016/j.jmb.2004.08.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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