1X81
Farnesyl transferase structure of Jansen compound
Summary for 1X81
Entry DOI | 10.2210/pdb1x81/pdb |
Related | 1NI1 |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (4 entities in total) |
Functional Keywords | fanesyltransferase, transferase |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 2 |
Total formula weight | 83062.40 |
Authors | Li, Q.,Claiborne, A.,Li, T.,Hasvold, L.,Stoll, V.S.,Muchmore, S.,Jakob, C.G.,Gu, W.,Cohen, J.,Hutchins, C.,Frost, D.,Rosenberg, S.H.,Sham, H.L. (deposition date: 2004-08-16, release date: 2004-12-21, Last modification date: 2024-02-14) |
Primary citation | Li, Q.,Claiborne, A.,Li, T.,Hasvold, L.,Stoll, V.S.,Muchmore, S.,Jakob, C.G.,Gu, W.,Cohen, J.,Hutchins, C.,Frost, D.,Rosenberg, S.H.,Sham, H.L. Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors. Bioorg.Med.Chem.Lett., 14:5367-5370, 2004 Cited by PubMed: 15454228DOI: 10.1016/j.bmcl.2004.08.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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