1X2R

Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2

Summary for 1X2R

• Entry DOI: 10.2210/pdb1x2r/pdb
• Related: 1X2J
• Descriptor: Kelch-like ECH-associated protein 1, Nuclear factor erythroid 2 related factor 2, SULFATE ION, ... (4 entities in total)
• Functional Keywords: beta propeller, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription
• Biological source: Mus musculus (house mouse); More
• Cellular location: Cytoplasm: Q9Z2X8; Cytoplasm, cytosol: Q60795
• Total number of polymer chains: 2
• Total formula weight: 36628.56

Authors

Padmanabhan, B.,Tong, K.I.,Nakamura, Y.,Ohta, T.,Scharlock, M.,Kobayashi, A.,Ohtsuji, M.,Kang, M.-I.,Yamamoto, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2005-04-26, release date: 2006-03-07, Last modification date: 2023-10-25)

• Primary citation: Padmanabhan, B.,Tong, K.I.,Ohta, T.,Nakamura, Y.,Scharlock, M.,Ohtsuji, M.,Kang, M.-I.,Kobayashi, A.,Yokoyama, S.,Yamamoto, M.; Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer; Mol.Cell, 21:689-700, 2006; PubMed: 16507366; DOI: 10.1016/j.molcel.2006.01.013

Experimental method

X-RAY DIFFRACTION (1.7 Å)