1X2R
Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kelch-like ECH-associated protein 1 | polymer | 316 | 34711.9 | 1 | UniProt (Q9Z2X8) Pfam (PF01344) | Mus musculus (house mouse) | Cytosolic inhibitor of Nrf2 |
| 2 | B (B) | Nuclear factor erythroid 2 related factor 2 | polymer | 9 | 1052.1 | 1 | UniProt (Q60795) | NF-E2 related factor 2, NFE2-related factor 2, Nuclear factor, erythroid derived 2, like 2 | |
| 3 | C, D, E, F, G... (A) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 4 | L, M (A, B) | water | water | 18.0 | 424 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35764.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 864.6 | |
| All* | Total formula weight | 36628.6 |
