1WW3
Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase
Summary for 1WW3
Entry DOI | 10.2210/pdb1ww3/pdb |
Related | 1WW2 2PRJ |
Descriptor | Glycogen phosphorylase, muscle form, N-(trifluoroacetyl)-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total) |
Functional Keywords | glycogenolysis, type 2 diabetes, transferase |
Biological source | Oryctolagus cuniculus (rabbit) |
Total number of polymer chains | 1 |
Total formula weight | 97813.52 |
Authors | Anagnostou, E.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Hadjiloi, T.,Tiraidis, C.,Zographos, S.E.,Gyorgydeak, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Kolisis, F.N.,Oikonomakos, N.G. (deposition date: 2004-12-31, release date: 2005-12-13, Last modification date: 2023-10-25) |
Primary citation | Anagnostou, E.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Hadjiloi, T.,Tiraidis, C.,Zographos, S.E.,Gyorgydeak, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Kolisis, F.N.,Oikonomakos, N.G. Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-d-glucopyranosylamine and N-trifluoroacetyl-beta-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Bioorg.Med.Chem., 14:181-189, 2006 Cited by PubMed: 16213146DOI: 10.1016/j.bmc.2005.08.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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