1WW3
Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glycogen phosphorylase, muscle form | polymer | 842 | 97291.2 | 1 | UniProt (P00489) Pfam (PF00343) | Oryctolagus cuniculus (rabbit) | Myophosphorylase |
| 2 | B (A) | N-(trifluoroacetyl)-beta-D-glucopyranosylamine | non-polymer | 275.2 | 1 | Chemie (NTF) | |||
| 3 | C (A) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 1 | Chemie (PLP) | |||
| 4 | D (A) | water | water | 18.0 | 402 | Chemie (HOH) |
Sequence modifications
A: 1 - 842 (UniProt: P00489)
| PDB | External Database | Details |
|---|---|---|
| Ile 380 | Leu 380 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 97291.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 522.3 | |
| All* | Total formula weight | 97813.5 |
